Enhancing Diagnostic Accuracy in Rare and Common Fundus Diseases with a Knowledge-Rich Vision-Language Model

Meng Wang; Tian Lin; Aidi Lin; Kai Yu; Yuanyuan Peng; Lianyu Wang; Cheng Chen; Ke Zou; Huiyu Liang; Man Chen; Xue Yao; Meiqin Zhang; Binwei Huang; Chaoxin Zheng; Peixin Zhang; Wei Chen; Yilong Luo; Yifan Chen; Honghe Xia; Tingkun Shi; Qi Zhang; Jinming Guo; Xiaolin Chen; Jingcheng Wang; Yih Chung Tham; Dianbo Liu; Wendy Wong; Sahil Thakur; Beau Fenner; Danqi Fang; Siying Liu; Qingyun Liu; Yuqiang Huang; Hongqiang Zeng; Yanda Meng; Yukun Zhou; Zehua Jiang; Minghui Qiu; Changqing Zhang; Xinjian Chen; Sophia Y. Wang; Cecilia S. Lee; Lucia Sobrin; Carol Y Cheung; Chi Pui Pang; Pearse A. Keane; Ching-Yu Cheng; Haoyu Chen; Huazhu Fu

arXiv · 2406.09317

Enhancing Diagnostic Accuracy in Rare and Common Fundus Diseases with a Knowledge-Rich Vision-Language Model

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Abstract

Previous foundation models for fundus images were pre-trained with limited disease categories and knowledge base. Here we introduce a knowledge-rich vision-language model (RetiZero) that leverages knowledge from more than 400 fundus diseases. For RetiZero's pretraining, we compiled 341,896 fundus images paired with texts, sourced from public datasets, ophthalmic literature, and online resources, encompassing a diverse range of diseases across multiple ethnicities and countries. RetiZero exhibits remarkable performance in several downstream tasks, including zero-shot disease recognition, image-to-image retrieval, AI-assisted clinical diagnosis,few-shot fine-tuning, and internal- and cross-domain disease identification. In zero-shot scenarios, RetiZero achieves Top-5 accuracies of 0.843 for 15 diseases and 0.756 for 52 diseases. For image retrieval, it achieves Top-5 scores of 0.950 and 0.886 for the same sets, respectively. AI-assisted clinical diagnosis results show that RetiZero's Top-3 zero-shot performance surpasses the average of 19 ophthalmologists from Singapore, China, and the United States. RetiZero substantially enhances clinicians' accuracy in diagnosing fundus diseases, in particularly rare ones. These findings underscore the value of integrating the RetiZero into clinical settings, where various fundus diseases are encountered.

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Meng Wang, Tian Lin, Aidi Lin, Kai Yu, Yuanyuan Peng, Lianyu Wang, Cheng Chen, Ke Zou, Huiyu Liang, Man Chen, Xue Yao, Meiqin Zhang, Binwei Huang, Chaoxin Zheng, Peixin Zhang, Wei Chen, Yilong Luo, Yifan Chen, Honghe Xia, Tingkun Shi, Qi Zhang, Jinming Guo, Xiaolin Chen, Jingcheng Wang, Yih Chung Tham, Dianbo Liu, Wendy Wong, Sahil Thakur, Beau Fenner, Danqi Fang, Siying Liu, Qingyun Liu, Yuqiang Huang, Hongqiang Zeng, Yanda Meng, Yukun Zhou, Zehua Jiang, Minghui Qiu, Changqing Zhang, Xinjian Chen, Sophia Y. Wang, Cecilia S. Lee, Lucia Sobrin, Carol Y Cheung, Chi Pui Pang, Pearse A. Keane, Ching-Yu Cheng, Haoyu Chen, Huazhu Fu. 2024-06-13. Enhancing Diagnostic Accuracy in Rare and Common Fundus Diseases with a Knowledge-Rich Vision-Language Model. https://arxiv.org/abs/2406.09317

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