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arXiv · 2408.03676

Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure

Valentina Buonfiglio·Niccolò Zagli·Irene Pertici·Vincenzo Lombardi·Pasquale Bianco·Duccio Fanelli
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Abstract

A data fitting procedure is devised and thoroughly tested to provide self-consistent estimates of the relevant mechanokinetic parameters involved in a plausible scheme underpinning the output of an ensemble of myosin II molecular motors mimicking the muscle contraction. The method builds on a stochastic model accounting for the force exerted by the motor ensemble operated both in the low and high force-generating regimes corresponding to different temperature ranges. The proposed interpretative framework is successfully challenged against simulated data, meant to mimic the experimental output of a unidimensional synthetic nanomachine powered by pure muscle myosin isoforms.

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Valentina Buonfiglio, Niccolò Zagli, Irene Pertici, Vincenzo Lombardi, Pasquale Bianco, Duccio Fanelli. 2024-08-07. Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure. https://arxiv.org/abs/2408.03676

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