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arXiv · 2409.10107

The i-TED Compton Camera Array for real-time boron imaging and determination during treatments in Boron Neutron Capture Therapy

Pablo Torres-Sánchez·Jorge Lerendegui-Marco·Javier Balibrea-Correa·Victor Babiano-Suárez·Bernardo Gameiro·Ion Ladarescu·Patricia Álvarez-Rodríguez·Jean-Michel Daugas·Ulli Koester·Caterina Michelagnoli·Maria Pedrosa-Rivera·Ignacio Porras·Maria José Ruiz-Magaña·Carmen Ruiz-Ruiz·César Domingo-Pardo
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Abstract

This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT. Additionally, advanced 3D image reconstruction algorithms, including a combination of back-projection and List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are implemented and validated through simulations. Preliminary experimental tests at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a clinical setting, with ongoing experiments focusing on improving imaging capabilities in realistic BNCT conditions.

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Pablo Torres-Sánchez, Jorge Lerendegui-Marco, Javier Balibrea-Correa, Victor Babiano-Suárez, Bernardo Gameiro, Ion Ladarescu, Patricia Álvarez-Rodríguez, Jean-Michel Daugas, Ulli Koester, Caterina Michelagnoli, Maria Pedrosa-Rivera, Ignacio Porras, Maria José Ruiz-Magaña, Carmen Ruiz-Ruiz, César Domingo-Pardo. 2024-09-16. The i-TED Compton Camera Array for real-time boron imaging and determination during treatments in Boron Neutron Capture Therapy. https://doi.org/10.1016/j.apradiso.2024.111649

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