Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 2502.16986

A framework for rapid, reproducible, and high-fidelity whole-brain multi-pool CEST imaging at 3T

Yupeng Wu·Siyuan Fang·Siyuan Wang·Caixia Fu·Jianqi Li
View original source ↗Read source document ↗Export metadata ↓

Abstract

Purpose: To develop and validate a framework for rapid, accurate, and reproducible whole-brain, multi-pool chemical exchange saturation transfer (CEST) imaging at 3T, addressing challenges of long acquisition times and confounding factors. Methods: A single-shot 3D true fast imaging with steady-state precession (True FISP) sequence was optimized for whole-brain multi-pool CEST. Rapid B0, B1, and T1 mapping was performed using a dual-echo modified four-angle method. A feed-forward neural network was developed for rapid B1 correction, trained against the conventional multi-power method. The apparent exchange-dependent relaxation (AREX) metric was used to correct for T1 and magnetization transfer (MT) effects. The framework was validated in phantoms and healthy human subjects (N=8), including a test-retest reproducibility assessment. Results: The True FISP sequence yielded high-quality, whole-brain images with minimal artifacts and distortion in a clinically feasible scan time (~9 minutes). Phantom studies confirmed the effectiveness of B1 correction (coefficient of variation [CV] for MT_MTRLD decreased from 22.49% to 4.61%) and AREX-based confounder correction (CV for APT_AREX reduced from 33.6% to 6.9%). The neural network B1 correction showed excellent agreement with the conventional multi-power method in vivo (ICC > 0.97). High test-retest reproducibility was demonstrated across 96 brain regions, with the average CV for APT_AREX under 10% for over 95% of regions. Conclusion: A rapid and robust framework for whole-brain quantitative multi-pool CEST imaging was successfully developed and validated. By integrating an efficient acquisition sequence with a streamlined correction pipeline, this approach overcomes key barriers to clinical translation, enabling reliable metabolic imaging for widespread brain pathologies.

Explore related subjects

physics.med-ph

Keep this discovery

BibTeXRIS

Yupeng Wu, Siyuan Fang, Siyuan Wang, Caixia Fu, Jianqi Li. 2025-02-24. A framework for rapid, reproducible, and high-fidelity whole-brain multi-pool CEST imaging at 3T. https://arxiv.org/abs/2502.16986

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Phase-contrast micro-CT for intra-operative breast tumour margin assessment using a microfocus x-ray source and photon-counting detector

Objective: Intra-operative tumour margin assessment during breast-conserving surgery requires rapid, high-resolution imaging of excised tissue, allowing the surgical team to take appropriate action within a single operation. This study evaluates a custom propagation-based phase-contrast micro-computed tomography (micro-CT) system designed to meet these clinical constraints without specialised optical elements. Methods: The experimental setup pairs a microfocus x-ray source with a photon-counting detector in a cone-beam geometry. We explore how the spatial coherence of the source can provide propagation-based phase contrast -- with no additional specialised optical elements -- and balance this against maximising the x-ray flux of the cone-beam geometry. System performance was evaluated across two anode target materials and filtration configurations at various tube power settings. Imaging capabilities were validated using anthropomorphic breast tissue phantoms and a formalin-fixed paraffin-embedded (FFPE) breast tissue specimen, with reconstructions compared against gold-standard histology. Results: An unfiltered tungsten target operated at 40 kVp yielded optimal image quality. The optimised system achieved high-resolution CT reconstructions of a 5 cm diameter sample with an isotropic voxel size of 40.7 $\upmu\text{m}$ in a scan time of 12 minutes. Reconstructed volumes demonstrated strong visual correlation with corresponding histology slides. Conclusion: Combining a microfocus source with a photon-counting detector enables high-resolution, phase-contrast micro-CT within a clinically viable timeframe, demonstrating strong potential for intra-operative margin assessment.

physics.med-ph↗
arXiv2026

Understanding Search and Decision Errors in Liver Metastasis Detection and the Effects of Lower Radiation Dose

The detection performance of liver metastases decreases with the reduction of radiation dose, but misses are heterogeneous. Previous eye tracking work has characterized missed metastases into two categories: search errors i.e., the eyes never land on the lesion, and decision errors i.e., the lesion is seen but not recognized as malignant. We integrated three prior reader studies to answer this question. In all studies, radiologists interpreted the same set of 40 contrast enhanced abdominal CT exams containing 91 liver metastases whose locations had been previously marked. In two studies, the workstation recorded their gaze and eye movements. Using eye dwell times, metastases were classified as search-error-dominant (majority of misses had <2 sec gaze time) or decision-error-dominant (>2 sec gaze time). In the third study, exams were interpreted both at 120 and 200 quality reference mAs (QRM) by ten radiologists. The third study did not include eye tracking. Out of 91 liver metastases, we excluded 16 that were never missed in the eye tracking studies and used 75 liver metastases for the present study.

physics.med-ph↗
arXiv2026

Develop and Optimize 5DCT Imaging Simulation and Reconstruction Methods

Purpose: To develop and optimize a 5DCT (3D + cardiac phase + respiratory phase) imaging simulation and reconstruction pipeline, and to compare two sinogram-space interpolation methods for reconstructing images at arbitrary combinations of cardiac and respiratory phase. Methods: Helical CT projections were simulated from the 4D XCAT phantom across a range of cardiac and respiratory motion states, with Poisson and electronic noise added. Ground-truth-matched volumes were generated at 5 cardiac phases and 10 respiratory amplitudes (50 total phase combinations). Because acquired projections are sparsely and unevenly distributed across this joint phase space, each target slice was reconstructed by interpolating rebinned sinogram rows to the target cardiac phase and respiratory amplitude, using either 2D scattered barycentric interpolation or 2D scattered local linear interpolation with a circular kernel for cardiac phase. Reconstructed volumes were compared to phantom ground truth using mean absolute error (MAE), and to conventional respiratory-gated 4DCT (r4DCT) reconstructed from the same simulated data. Results: Both interpolation methods eliminated the severe axial misalignment artifacts present when helical projections were reconstructed without phase-space interpolation. Local linear interpolation achieved lower MAE than barycentric interpolation across most tested conditions, with the largest improvement at low pitch. The 5DCT pipeline also produced respiratory-only volumes with fewer residual cardiac-motion artifacts than conventional r4DCT reconstructed from the same projection data, including at standard clinical pitch (0.1). Conclusions: 5DCT reconstruction using sinogram-space interpolation is feasible and can jointly resolve cardiac and respiratory motion with better accuracy than conventional 4DCT reconstruction.

physics.med-ph↗