ROFI: A Deep Learning-Based Ophthalmic Sign-Preserving and Reversible Patient Face Anonymizer

Yuan Tian; Min Zhou; Yitong Chen; Fang Li; Lingzi Qi; Shuo Wang; Xieyang Xu; Yu Yu; Shiqiong Xu; Chaoyu Lei; Yankai Jiang; Rongzhao Zhang; Jia Tan; Li Wu; Hong Chen; Xiaowei Liu; Wei Lu; Lin Li; Huifang Zhou; Xuefei Song; Guangtao Zhai; Xianqun Fan

arXiv · 2510.11073

ROFI: A Deep Learning-Based Ophthalmic Sign-Preserving and Reversible Patient Face Anonymizer

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Abstract

Patient face images provide a convenient mean for evaluating eye diseases, while also raising privacy concerns. Here, we introduce ROFI, a deep learning-based privacy protection framework for ophthalmology. Using weakly supervised learning and neural identity translation, ROFI anonymizes facial features while retaining disease features (over 98\% accuracy, $\kappa > 0.90$). It achieves 100\% diagnostic sensitivity and high agreement ($\kappa > 0.90$) across eleven eye diseases in three cohorts, anonymizing over 95\% of images. ROFI works with AI systems, maintaining original diagnoses ($\kappa > 0.80$), and supports secure image reversal (over 98\% similarity), enabling audits and long-term care. These results show ROFI's effectiveness of protecting patient privacy in the digital medicine era.

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Yuan Tian, Min Zhou, Yitong Chen, Fang Li, Lingzi Qi, Shuo Wang, Xieyang Xu, Yu Yu, Shiqiong Xu, Chaoyu Lei, Yankai Jiang, Rongzhao Zhang, Jia Tan, Li Wu, Hong Chen, Xiaowei Liu, Wei Lu, Lin Li, Huifang Zhou, Xuefei Song, Guangtao Zhai, Xianqun Fan. 2025-10-13. ROFI: A Deep Learning-Based Ophthalmic Sign-Preserving and Reversible Patient Face Anonymizer. https://arxiv.org/abs/2510.11073

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