Swelling-Induced Stress-Assisted Transfer of Nanodiamond Arrays with a PVA Carrier Tape for Conformal Bio-Integrated Sensing and Labelling

Abstract

The conformal integration of nitrogen-vacancy (NV) center nanodiamond arrays onto soft, hydrated, curvilinear biological interfaces remain a fundamental challenge for in vivo quantum sensing and imaging. Conventional transfer techniques often fail due to reliance on high temperature, corrosive chemicals, or mechanical peeling, leading to pattern damage, low fidelity, or poor biocompatibility. Here, we report a transfer strategy utilizing polyvinyl alcohol (PVA) carrier soluble tape, enabling rapid, residue-free, high-fidelity transfer of nanodiamond patterns onto diverse biointerfaces. The success of this method is rooted in a unique "hydrate-soften-expand-self-peel" mechanism of the soluble tape with PVA backing. In situ mechanical tracking reveals non-uniform PVA swelling upon hydration generates transient local normal and shear stresses at the interface. These stresses delaminate the tape within 3 minutes at room temperature while promoting adhesion of the nanodiamond array to the substrate. In contrast, conventional water-soluble tapes with composite structures undergo passive dissolution and collapse, causing residue contamination and reduced efficiency. Leveraging this mechanism, we achieve conformal patterning on ultra-soft hydrogels (~0.6 kPa) and highly curved bio-surfaces (hair, 100 {\mu}m^-1). Additionally, we demonstrate a dual-identity verification system integrating data storage and physical unclonable functions on a hydrogel contact lens. This work provides a versatile tool for bio-interface engineering and a general framework for gentle, efficient transfer of functional nanomaterials.