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arXiv · 2605.05924

Injectable Thermochemical Micro-Explosion for Prompt Thrombolysis via Liquid Alkali Metal

Xin Liao·Yi Hou·Jie Zhang·Bo Wang·Minghui Guo·Hua Qu·Wei Rao·Jing Liu
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Abstract

Thrombotic vascular diseases contribute to significant global mortality, yet current therapeutic strategies face persistent challenges including bleeding risks, suboptimal efficiency, and procedural complexity. Here, we report a micro-explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal (LAM) encapsulated in dimethyl silicone (LAM@oil), which enables prompt, efficient and safe vascular recanalization within an ultrafast timeframe (< 90 seconds). This LAM@oil system effectively disrupts thrombus tissue through a synergistic triple-action mechanism: Mechanical micro-explosions forces, alkaline ablation due to highly localized exothermic chemical reactions, and thermal thrombolysis mediated by elevated temperature. Upon thrombolysis completion, the non-toxic reaction byproducts (sodium and potassium ions) exhibit physiologically biocompatible and metabolizable effects. Critically, the LAM@oil demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic drugs (residual thrombus area percent 10.87%+-7.16% for LAM@oil vs. 80.86%+-13.32% for urokinase), with no associated bleeding risks. This strategy opens a byproduct-free, cost-effective, and high-efficiency alternative to conventional thrombolytics, holding big potential for clinical translation in acute thrombosis management.

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Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu. 2026-05-07. Injectable Thermochemical Micro-Explosion for Prompt Thrombolysis via Liquid Alkali Metal. https://arxiv.org/abs/2605.05924

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