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arXiv · 2608.28275

Full-field fluorescence computed tomography (F3CT) using a calibrated virtual cone-beam pinhole geometry

Thomas Zillhardt·Yunhui Chen·Alexander Rack·Matthew Veale·Matt Wilson·Philip J. Withers·Nicola Viganò
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Abstract

We present F3CT, a synchrotron-based hyperspectral full-field fluorescence computed tomography technique that avoids raster scanning by combining a pinhole aperture with an energy-resolving 2D detector. A virtual cone-beam model and two-stage calibration-reconstruction workflow enable 3D elemental mapping under full-field illumination. The method is demonstrated on biological and geological specimens, resolving silver-stain distributions in zebrafish tissue and high-energy fluorescence signatures in rock cores. Phase-contrast tomograms acquired sequentially under the same experimental geometry provide co-registered structural context. F3CT provides a high-throughput route to 3D XRF imaging and establishes a foundation for correlated structural and chemical tomography, with potential for future in-situ and operando implementations.

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Thomas Zillhardt, Yunhui Chen, Alexander Rack, Matthew Veale, Matt Wilson, Philip J. Withers, Nicola Viganò. 2026-08-28. Full-field fluorescence computed tomography (F3CT) using a calibrated virtual cone-beam pinhole geometry. https://arxiv.org/abs/2608.28275

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