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Igor Prünster

Publications and source records attributed to Igor Prünster.

At least 19 recordsLinked to original sources

Principled Estimation and Prediction with Competing Risks: a Bayesian Nonparametric Approach

Competing risks occur in survival analysis when multiple causes of death are present. They play a prominent role in several domains extending beyond biostatistics to encompass epidemiology, actuarial sciences, and reliability theory. This paper adopts a multi-state modeling framework to competing risks. We introduce a class of flexible nonparametric priors, defined through hierarchical completely random measures, to model the transition probabilities, and identify the specific (conditionally) conjugate member of this general class. Furthermore, we determine the joint marginal distribution of the data and of a latent random partition, and characterize the posterior distribution of the model. Leveraging these distributional results, we evaluate the predictive probability that a future event is of a specific type (e.g. death from a particular cause), as a function of the time at which the event occurs. The resulting function, derived on sound principles, is termed the prediction curve, and represents a major innovation in the literature. In addition, we provide posterior estimates for the survival function, and for the cause-specific incidence and subdistribution functions. Suitable simulation algorithms for posterior inference are also devised. The model's performance, as well as the algorithms' effectiveness, is evaluated through simulation studies. Finally, we illustrate our approach on clinical datasets.

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Species Sensitivity Distribution revisited: a Bayesian nonparametric approach

We present a novel approach to ecological risk assessment by recasting the Species Sensitivity Distribution (SSD) method within a Bayesian nonparametric (BNP) framework. Widely mandated by environmental regulatory bodies globally, SSD has faced criticism due to its historical reliance on parametric assumptions when modeling species variability. By adopting nonparametric mixture models, we address this limitation, establishing a statistically robust foundation for SSD. Our BNP approach offers several advantages, including its efficacy in handling small datasets or censored data, which are common in ecological risk assessment, and its ability to provide principled uncertainty quantification alongside simultaneous density estimation and clustering. We utilize a specific nonparametric prior as the mixing measure, chosen for its robust clustering properties, a crucial consideration given the lack of strong prior beliefs about the number of components. Through simulation studies and analysis of real datasets, we demonstrate the superiority of our BNP-SSD over classical SSD methods. We also provide a BNP-SSD Shiny application, making our methodology available to the Ecotoxicology community. Moreover, we exploit the inherent clustering structure of the mixture model to explore patterns in species sensitivity. Our findings underscore the effectiveness of the proposed approach in improving ecological risk assessment methodologies.

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Multivariate Species Sampling Models

Species sampling processes have long served as the fundamental framework for modeling random discrete distributions and exchangeable sequences. However, data arising from distinct but related sources require a broader notion of probabilistic invariance, making partial exchangeability a natural choice. Countless models for partially exchangeable data, collectively known as dependent nonparametric priors, have been proposed. These include hierarchical, nested and additive processes, widely used in statistics and machine learning. Still, a unifying framework is lacking and key questions about their underlying learning mechanisms remain unanswered. We fill this gap by introducing multivariate species sampling models, a new general class of nonparametric priors that encompasses most existing finite- and infinite-dimensional dependent processes. They are characterized by the induced partially exchangeable partition probability function encoding their multivariate clustering structure. We establish their core distributional properties and analyze their dependence structure, demonstrating that borrowing of information across groups is entirely determined by shared ties. This provides new insights into the underlying learning mechanisms, offering, for instance, a principled rationale for the previously unexplained correlation structure observed in existing models. Beyond providing a cohesive theoretical foundation, our approach serves as a constructive tool for developing new models and opens novel research directions for capturing richer dependence structures beyond the framework of multivariate species sampling processes.

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Markov Stick-breaking Processes

Stick-breaking has a long history and is one of the most popular procedures for constructing random discrete distributions in Statistics and Machine Learning. In particular, due to their intuitive construction and computational tractability they are ubiquitous in modern Bayesian nonparametric inference. Most widely used models, such as the Dirichlet and the Pitman-Yor processes, rely on iid or independent length variables. Here we pursue a completely unexplored research direction by considering Markov length variables and investigate the corresponding general class of stick-breaking processes, which we term Markov stick-breaking processes. We establish conditions under which the associated species sampling process is proper and the distribution of a Markov stick-breaking process has full topological support, two fundamental desiderata for Bayesian nonparametric models. We also analyze the stochastic ordering of the weights and provide a new characterization of the Pitman-Yor process as the only stick-breaking process invariant under size-biased permutations, under mild conditions. Moreover, we identify two notable subclasses of Markov stick-breaking processes that enjoy appealing properties and include Dirichlet, Pitman-Yor and Geometric priors as special cases. Our findings include distributional results enabling posterior inference algorithms and methodological insights.

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Partially exchangeable stochastic block models for (node-colored) multilayer networks

Multilayer networks generalize single-layered connectivity data in several directions. These generalizations include, among others, settings where multiple types of edges are observed among the same set of nodes (edge-colored networks) or where a single notion of connectivity is measured between nodes belonging to different pre-specified layers (node-colored networks). While progress has been made in statistical modeling of edge-colored networks, principled approaches that flexibly account for both within and across layer block-connectivity structures while incorporating layer information through a rigorous probabilistic construction are still lacking for node-colored multilayer networks. We fill this gap by introducing a novel class of partially exchangeable stochastic block models specified in terms of a hierarchical random partition prior for the allocation of nodes to groups, whose number is learned by the model. This goal is achieved without jeopardizing probabilistic coherence, uncertainty quantification and derivation of closed-form predictive within- and across-layer co-clustering probabilities. Our approach facilitates prior elicitation, the understanding of theoretical properties and the development of yet-unexplored predictive strategies for both the connections and the allocations of future incoming nodes. Posterior inference proceeds via a tractable collapsed Gibbs sampler, while performance is illustrated in simulations and in a real-world criminal network application. The notable gains achieved over competitors clarify the importance of developing general stochastic block models based on suitable node-exchangeability structures coherent with the type of multilayer network being analyzed.

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Nonparametric priors with full-range borrowing of information

Modeling of the dependence structure across heterogeneous data is crucial for Bayesian inference since it directly impacts the borrowing of information. Despite the extensive advances over the last two decades, most available proposals allow only for non-negative correlations. We derive a new class of dependent nonparametric priors that can induce correlations of any sign, thus introducing a new and more flexible idea of borrowing of information. This is achieved thanks to a novel concept, which we term hyper-tie, and represents a direct and simple measure of dependence. We investigate prior and posterior distributional properties of the model and develop algorithms to perform posterior inference. Illustrative examples on simulated and real data show that our proposal outperforms alternatives in terms of prediction and clustering.

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A Wasserstein index of dependence for random measures

Optimal transport and Wasserstein distances are flourishing in many scientific fields as a means for comparing and connecting random structures. Here we pioneer the use of an optimal transport distance between Lévy measures to solve a statistical problem. Dependent Bayesian nonparametric models provide flexible inference on distinct, yet related, groups of observations. Each component of a vector of random measures models a group of exchangeable observations, while their dependence regulates the borrowing of information across groups. We derive the first statistical index of dependence in $[0,1]$ for (completely) random measures that accounts for their whole infinite-dimensional distribution, which is assumed to be equal across different groups. This is accomplished by using the geometric properties of the Wasserstein distance to solve a max-min problem at the level of the underlying Lévy measures. The Wasserstein index of dependence sheds light on the models' deep structure and has desirable properties: (i) it is $0$ if and only if the random measures are independent; (ii) it is $1$ if and only if the random measures are completely dependent; (iii) it simultaneously quantifies the dependence of $d \ge 2$ random measures, avoiding the need for pairwise comparisons; (iv) it can be evaluated numerically. Moreover, the index allows for informed prior specifications and fair model comparisons for Bayesian nonparametric models.

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Model Selection for Maternal Hypertensive Disorders with Symmetric Hierarchical Dirichlet Processes

Hypertensive disorders of pregnancy occur in about 10% of pregnant women around the world. Though there is evidence that hypertension impacts maternal cardiac functions, the relation between hypertension and cardiac dysfunctions is only partially understood. The study of this relationship can be framed as a joint inferential problem on multiple populations, each corresponding to a different hypertensive disorder diagnosis, that combines multivariate information provided by a collection of cardiac function indexes. A Bayesian nonparametric approach seems particularly suited for this setup and we demonstrate it on a dataset consisting of transthoracic echocardiography results of a cohort of Indian pregnant women. We are able to perform model selection, provide density estimates of cardiac function indexes and a latent clustering of patients: these readily interpretable inferential outputs allow to single out modified cardiac functions in hypertensive patients compared to healthy subjects and progressively increased alterations with the severity of the disorder. The analysis is based on a Bayesian nonparametric model that relies on a novel hierarchical structure, called symmetric hierarchical Dirichlet process. This is suitably designed so that the mean parameters are identified and used for model selection across populations, a penalization for multiplicity is enforced, and the presence of unobserved relevant factors is investigated through a latent clustering of subjects. Posterior inference relies on a suitable Markov Chain Monte Carlo algorithm and the model behaviour is also showcased on simulated data.

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Flexible clustering via hidden hierarchical Dirichlet priors

The Bayesian approach to inference stands out for naturally allowing borrowing information across heterogeneous populations, with different samples possibly sharing the same distribution. A popular Bayesian nonparametric model for clustering probability distributions is the nested Dirichlet process, which however has the drawback of grouping distributions in a single cluster when ties are observed across samples. With the goal of achieving a flexible and effective clustering method for both samples and observations, we investigate a nonparametric prior that arises as the composition of two different discrete random structures and derive a closed-form expression for the induced distribution of the random partition, the fundamental tool regulating the clustering behavior of the model. On the one hand, this allows to gain a deeper insight into the theoretical properties of the model and, on the other hand, it yields an MCMC algorithm for evaluating Bayesian inferences of interest. Moreover, we single out limitations of this algorithm when working with more than two populations and, consequently, devise an alternative more efficient sampling scheme, which as a by-product, allows testing homogeneity between different populations. Finally, we perform a comparison with the nested Dirichlet process and provide illustrative examples of both synthetic and real data.

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BNPdensity: Bayesian nonparametric mixture modeling in R

Robust statistical data modelling under potential model mis-specification often requires leaving the parametric world for the nonparametric. In the latter, parameters are infinite dimensional objects such as functions, probability distributions or infinite vectors. In the Bayesian nonparametric approach, prior distributions are designed for these parameters, which provide a handle to manage the complexity of nonparametric models in practice. However, most modern Bayesian nonparametric models seem often out of reach to practitioners, as inference algorithms need careful design to deal with the infinite number of parameters. The aim of this work is to facilitate the journey by providing computational tools for Bayesian nonparametric inference. The article describes a set of functions available in the \R package BNPdensity in order to carry out density estimation with an infinite mixture model, including all types of censored data. The package provides access to a large class of such models based on normalized random measures, which represent a generalization of the popular Dirichlet process mixture. One striking advantage of this generalization is that it offers much more robust priors on the number of clusters than the Dirichlet. Another crucial advantage is the complete flexibility in specifying the prior for the scale and location parameters of the clusters, because conjugacy is not required. Inference is performed using a theoretically grounded approximate sampling methodology known as the Ferguson & Klass algorithm. The package also offers several goodness of fit diagnostics such as QQ-plots, including a cross-validation criterion, the conditional predictive ordinate. The proposed methodology is illustrated on a classical ecological risk assessment method called the Species Sensitivity Distribution (SSD) problem, showcasing the benefits of the Bayesian nonparametric framework.

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Inner spike and slab Bayesian nonparametric models

Discrete Bayesian nonparametric models whose expectation is a convex linear combination of a point mass at some point of the support and a diffuse probability distribution allow to incorporate strong prior information, while still being extremely flexible. Recent contributions in the statistical literature have successfully implemented such a modelling strategy in a variety of applications, including density estimation, nonparametric regression and model-based clustering. We provide a thorough study of a large class of nonparametric models we call inner spike and slab hNRMI models, which are obtained by considering homogeneous normalized random measures with independent increments (hNRMI) with base measure given by a convex linear combination of a point mass and a diffuse probability distribution. In this paper we investigate the distributional properties of these models and our results include: i) the exchangeable partition probability function they induce, ii) the distribution of the number of distinct values in an exchangeable sample, iii) the posterior predictive distribution, and iv) the distribution of the number of elements that coincide with the only point of the support with positive probability. Our findings are the main building block for an actual implementation of Bayesian inner spike and slab hNRMI models by means of a generalized Pólya urn scheme.

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Asymptotic behavior of the number of distinct values in a sample from the geometric stick-breaking process

Discrete random probability measures are a key ingredient of Bayesian nonparametric inferential procedures. A sample generates ties with positive probability and a fundamental object of both theoretical and applied interest is the corresponding random number of distinct values. The growth rate can be determined from the rate of decay of the small frequencies implying that, when the decreasingly ordered frequencies admit a tractable form, the asymptotics of the number of distinct values can be conveniently assessed. We focus on the geometric stick-breaking process and we investigate the effect of the choice of the distribution for the success probability on the asymptotic behavior of the number of distinct values. We show that a whole range of logarithmic behaviors are obtained by appropriately tuning the prior. We also derive a two-term expansion and illustrate its use in a comparison with a larger family of discrete random probability measures having an additional parameter given by the scale of the negative binomial distribution.

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Latent nested nonparametric priors

Discrete random structures are important tools in Bayesian nonparametrics and the resulting models have proven effective in density estimation, clustering, topic modeling and prediction, among others. In this paper, we consider nested processes and study the dependence structures they induce. Dependence ranges between homogeneity, corresponding to full exchangeability, and maximum heterogeneity, corresponding to (unconditional) independence across samples. The popular nested Dirichlet process is shown to degenerate to the fully exchangeable case when there are ties across samples at the observed or latent level. To overcome this drawback, inherent to nesting general discrete random measures, we introduce a novel class of latent nested processes. These are obtained by adding common and group-specific completely random measures and, then, normalising to yield dependent random probability measures. We provide results on the partition distributions induced by latent nested processes, and develop an Markov Chain Monte Carlo sampler for Bayesian inferences. A test for distributional homogeneity across groups is obtained as a by product. The results and their inferential implications are showcased on synthetic and real data.

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A moment-matching Ferguson and Klass algorithm

Completely random measures (CRM) represent the key building block of a wide variety of popular stochastic models and play a pivotal role in modern Bayesian Nonparametrics. A popular representation of CRMs as a random series with decreasing jumps is due to Ferguson and Klass (1972). This can immediately be turned into an algorithm for sampling realizations of CRMs or more elaborate models involving transformed CRMs. However, concrete implementation requires to truncate the random series at some threshold resulting in an approximation error. The goal of this paper is to quantify the quality of the approximation by a moment-matching criterion, which consists in evaluating a measure of discrepancy between actual moments and moments based on the simulation output. Seen as a function of the truncation level, the methodology can be used to determine the truncation level needed to reach a certain level of precision. The resulting moment-matching \FK algorithm is then implemented and illustrated on several popular Bayesian nonparametric models.

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Bayesian inference with dependent normalized completely random measures

The proposal and study of dependent prior processes has been a major research focus in the recent Bayesian nonparametric literature. In this paper, we introduce a flexible class of dependent nonparametric priors, investigate their properties and derive a suitable sampling scheme which allows their concrete implementation. The proposed class is obtained by normalizing dependent completely random measures, where the dependence arises by virtue of a suitable construction of the Poisson random measures underlying the completely random measures. We first provide general distributional results for the whole class of dependent completely random measures and then we specialize them to two specific priors, which represent the natural candidates for concrete implementation due to their analytic tractability: the bivariate Dirichlet and normalized $σ$-stable processes. Our analytical results, and in particular the partially exchangeable partition probability function, form also the basis for the determination of a Markov Chain Monte Carlo algorithm for drawing posterior inferences, which reduces to the well-known Blackwell--MacQueen Pólya urn scheme in the univariate case. Such an algorithm can be used for density estimation and for analyzing the clustering structure of the data and is illustrated through a real two-sample dataset example.

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Modeling with Normalized Random Measure Mixture Models

The Dirichlet process mixture model and more general mixtures based on discrete random probability measures have been shown to be flexible and accurate models for density estimation and clustering. The goal of this paper is to illustrate the use of normalized random measures as mixing measures in nonparametric hierarchical mixture models and point out how possible computational issues can be successfully addressed. To this end, we first provide a concise and accessible introduction to normalized random measures with independent increments. Then, we explain in detail a particular way of sampling from the posterior using the Ferguson-Klass representation. We develop a thorough comparative analysis for location-scale mixtures that considers a set of alternatives for the mixture kernel and for the nonparametric component. Simulation results indicate that normalized random measure mixtures potentially represent a valid default choice for density estimation problems. As a byproduct of this study an R package to fit these models was produced and is available in the Comprehensive R Archive Network (CRAN).

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