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Litao Yang

Publications and source records attributed to Litao Yang.

17 recordsLinked to original sources

Clinically Aligned Geometry Constraints for Robust IVUS Vessel Boundary Segmentation

Intravascular ultrasound (IVUS) lumen and external elastic membrane (EEM) segmentation is important for quantitative coronary plaque burden assessment. Errors in lumen or EEM delineation directly propagate to plaque area, plaque burden and geometric measurements. However, standard methods prioritising overlap scores often suffer from boundary drift and topology errors, leading to inaccurate clinical measurements. We present GeoCat, a geometry-consistent network that processes 5-frame IVUS clips using dual Cartesian-polar encoders with cross-domain attention and temporal fusion. A differentiable geometry consistency loss directly supervises clinically relevant descriptors including diameters, orientations, and cross-sectional areas. The model is trained on 12,242 annotated frames from 146 patients acquired with two commercial IVUS systems. We evaluate performance using both segmentation accuracy and plaque-relevant clinical metrics, including Dice/IoU, boundary measures(95HD (mm), ASSD), topology violation rate, and clinical geometry errors (dmax/dmin, angles, and areas). On our dataset, GeoCat achieves a Dice of 0.93, reduces 95HD to 0.14 mm, and lowers topology violations to 1.0%. Importantly, it significantly improves geometric fidelity, yielding diameter errors of 0.13-0.16 mm and angular errors of ~8 degrees, supporting reliable plaque burden quantification.

cs.CV

Projection of purification performance for the RELICS experiment

The RELICS (REactor neutrino LIquid xenon Coherent elastic Scattering) experiment employs a dual-phase liquid xenon time projection chamber to search for Coherent Elastic Neutrino-Nucleus Scattering (CE$ν$NS) induced by reactor neutrinos. To detect these sub-keV nuclear recoils and minimize signal attenuation, it is critical to maintain a sufficiently low impurity concentration in the detector. This work presents a comprehensive purity evolution model developed to describe impurity migration inside the detector. Utilizing measured material outgassing rates as input parameters, the model incorporates non-uniform transport mechanisms of the impurities, including circulation, vaporization, and condensation. The model is validated using data from a dedicated prototype detector. Based on this validated model, projections for the purification performance of the upcoming RELICS-10 and RELICS-50 detectors are provided.

physics.ins-det

Sensitivity of the RECODE Reactor CEvNS Experiment to the Dark Axion Portal

Reactor CEvNS experiments provide a powerful probe of the physics beyond the Standard Model (BSM) with the intense flux of neutrinos, photons, and other particles produced in nuclear reactors. In this work, we investigate the sensitivity of reactor CEvNS experiments to the dark axion portal, which connects the axion or axion-like particle to the dark photon. We focus in particular on the RECODE experiment, while also considering other reactor-based experiments such as CONUS and MINER. We find that reactor CEvNS experiments offer enhanced sensitivity in the sub-MeV region compared with the existing constraints from B factories, and can probe the portal coupling down to $\mathcal{O}(10^{-3})$ for $G_{aγγ'}$.

hep-ph

Development of a dual-phase xenon time projection chamber prototype for the RELICS experiment

The RELICS (REactor neutrino LIquid xenon Coherent elastic Scattering) experiment aims to detect coherent elastic neutrino-nucleus scattering from reactor antineutrinos using a dual-phase xenon time projection chamber. To validate the detector concept and ensure technical reliability for the full-scale experiment, a dedicated prototype was designed, constructed, and operated. This work presents an overview of the design, construction, and operational performance of the prototype, with emphasis on its major subsystems, including the TPC, cryogenic and xenon purification systems, slow control, and data acquisition. During operation, the detector demonstrated the capability to achieve a sub-keV energy threshold required for the RELICS physics program, as reflected by a measured single electron gain of 34.30~$\pm$~0.01~(stat.)~PE/e$^-$ and the successful detection of 0.27~keV L-shell decay events from $^{37}$Ar. In addition, essential data analysis techniques and simulation frameworks were developed and validated, establishing the methodological foundation for future RELICS operations. The successful construction and operation of this prototype confirm the feasibility of the core technologies and provide a crucial experimental basis for the final RELICS detector.

physics.ins-det

OPGAgent: An Agent for Auditable Dental Panoramic X-ray Interpretation

Orthopantomograms (OPGs) are the standard panoramic radiograph in dentistry, used for full-arch screening across multiple diagnostic tasks. While Vision Language Models (VLMs) now allow multi-task OPG analysis through natural language, they underperform task-specific models on most individual tasks. Agentic systems that orchestrate specialized tools offer a path to both versatility and accuracy, this approach remains unexplored in the field of dental imaging. To address this gap, we propose OPGAgent, a multi-tool agentic system for auditable OPG interpretation. OPGAgent coordinates specialized perception modules with a consensus mechanism through three components: (1) a Hierarchical Evidence Gathering module that decomposes OPG analysis into global, quadrant, and tooth-level phases with dynamically invoking tools, (2) a Specialized Toolbox encapsulating spatial, detection, utility, and expert zoos, and (3) a Consensus Subagent that resolves conflicts through anatomical constraints. We further propose OPG-Bench, a structured-report protocol based on (Location, Field, Value) triples derived from real clinical reports, which enables a comprehensive review of findings and hallucinations, extending beyond the limitations of VQA indicators. On our OPG-Bench and the public MMOral-OPG benchmark, OPGAgent outperforms current dental VLMs and medical agent frameworks across both structured-report and VQA evaluation. Code will be released upon acceptance.

cs.CV

Design and characterization of a photosensor system for the RELICS experiment

In this paper, we present the design and characterization of a photosensor system developed for the RELICS experiment. An extended dynamic range base was designed to mitigate photomultiplier tube (PMT) saturation caused by intense cosmic muon backgrounds in the surface-level RELICS detector. The system employs dual readout from the anode and the seventh dynode to extend the linear response range of the PMT. In particular, our characterization and measurements of Hamamatsu R8520-406 PMTs confirm stable operation under positive high-voltage bias, extending the linear response range by more than an order of magnitude. Furthermore, a model of PMT saturation and recovery was developed to evaluate the influence of cosmic muon signals in the RELICS detector. The results demonstrate the system capability to detect coherent elastic neutrino-nucleus scattering signals under surface-level cosmic backgrounds, and suggest the potential to extend the scientific reach of RELICS to MeV-scale interactions.

physics.ins-det

Hunting for Axions in REactor neutrino COherent scattering Detection Experiment

Nuclear power plants are not only vital sources of clean energy but also powerful facilities for probing new physics beyond the Standard Model. Due to the intense gamma-ray flux and an appropriate energy conditions, they are particularly well-suited for searches of light hypothetical particles such as sub-MeV axions and axion-like particles (ALPs). In this work, we propose to search for the ALPs in the REactor Neutrino COherent scattering Detection Experiment (RECODE), where two low-threshold, high-purity germanium detectors are placed at 11 m (near point) and 22 m (far point) from a 3.4 GW nuclear reactor at Sanmen nuclear power plant. With a 10 kg$\cdot$year exposure, we demonstrate that the expected sensitivities to the ALP couplings to the electrons and photons are competitive with or surpass the available results from the beam-dump experiments. A planned upgrade to 100 kg$\cdot$year will fully cover the so-called {$\it$ cosmological triangle} region, probing unexplored parameter space relevant to axions.

hep-ph

Extending the sensitivity of heavy sterile neutrino searches with solar neutrino experiments

A sensitivity study of the search for heavy sterile neutrinos ($\nu_H$) in the MeV mass range using solar neutrino experiments is presented. $\nu_H$, with masses ranging from a few MeV up to around 15 MeV, can be produced in the Sun through $^8$B decay and subsequently decay into $\nu_e e^+ e^-$. Its flux and lifetime strongly depend on the mixing parameter $|U_{eH}|^2$ and mass $m_{\nu_H}$. The $\nu_H$ signal can be detected via its decay products, either the $e^+e^-$ pair or $\nu_e$, depending on whether $\nu_H$ decays inside or outside the detector. Expected signal yields for both detection methods (detecting $e^+e^-$ or $\nu_e$ signal) are presented across the full $|U_{eH}|^2$ and $m_{\nu_H}$ parameter space. These two methods are found to be complementary in different regions of the $|U_{eH}|^2$ and $m_{\nu_H}$ phase space. By combining both approaches, we anticipate observing at least a handful of signal events across most of the parameter space of $10^{-6} < |U_{eH}|^2 < 1$ and 2 MeV $< m_{\nu_H} < $ 14 MeV, assuming a 500-ton solar neutrino experiment operating for one year. Key variables, such as the energy spectra and opening angle of $\nu_e$ or $e^+e^-$ and the solar angle of $\nu_e$ and its scattered electron, are also discussed to help distinguish signal from major backgrounds, such as solar neutrino events.

hep-ph

A Multimodal Vision Foundation Model for Clinical Dermatology

Diagnosing and treating skin diseases require advanced visual skills across domains and the ability to synthesize information from multiple imaging modalities. While current deep learning models excel at specific tasks like skin cancer diagnosis from dermoscopic images, they struggle to meet the complex, multimodal requirements of clinical practice. Here, we introduce PanDerm, a multimodal dermatology foundation model pretrained through self-supervised learning on over 2 million real-world skin disease images from 11 clinical institutions across 4 imaging modalities. We evaluated PanDerm on 28 diverse benchmarks, including skin cancer screening, risk stratification, differential diagnosis of common and rare skin conditions, lesion segmentation, longitudinal monitoring, and metastasis prediction and prognosis. PanDerm achieved state-of-the-art performance across all evaluated tasks, often outperforming existing models when using only 10% of labeled data. We conducted three reader studies to assess PanDerm's potential clinical utility. PanDerm outperformed clinicians by 10.2% in early-stage melanoma detection through longitudinal analysis, improved clinicians' skin cancer diagnostic accuracy by 11% on dermoscopy images, and enhanced non-dermatologist healthcare providers' differential diagnosis by 16.5% across 128 skin conditions on clinical photographs. These results demonstrate PanDerm's potential to improve patient care across diverse clinical scenarios and serve as a model for developing multimodal foundation models in other medical specialties, potentially accelerating the integration of AI support in healthcare. The code can be found at https://github.com/SiyuanYan1/PanDerm.

cs.CV

Reactor neutrino liquid xenon coherent elastic scattering experiment

Coherent elastic neutrino-nucleus scattering (CEvNS) provides a unique probe for neutrino properties Beyond the Standard Model (BSM) physics. REactor neutrino LIquid xenon Coherent Scattering experiment (RELICS), a proposed reactor neutrino program using liquid xenon time projection chamber (LXeTPC) technology, aims to investigate the CEvNS process of antineutrinos off xenon atomic nuclei. In this work, the design of the experiment is studied and optimized based on Monte Carlo (MC) simulations. To achieve a sufficiently low energy threshold for CEvNS detection, an ionization-only analysis channel is adopted for RELICS. A high emission rate of delayed electrons after a big ionization signal is the major background, leading to an analysis threshold of 120 photo-electrons in the CEvNS search. The second largest background, nuclear recoils induced by cosmic-ray neutrons, is suppressed via a passive water shield. The physics potential of RELICS is explored with a 32 kg*yr exposure at a baseline of 25 m from a reactor core with a 3 GW thermal power. In an energy range of 120 to 300 PE, corresponding to an average nuclear recoil from 0.63 to 1.36 keV considering the liquid xenon response and detector-related effect, we expect 4639.7 CEvNS and 1687.8 background events. The sensitivity of RELICS to the weak mixing angle is investigated at a low momentum transfer. Our study shows that RELICS can further improve the constraints on the non-standard neutrino interaction (NSI) compared to the current best results.

hep-ex

Study of cosmogenic activation in $^{76}$Ge enriched germanium detectors during fabrication and transportation above ground

Rare event search experiments using germanium detectors are operated in underground laboratories to minimize the background induced by cosmic rays. However, the cosmogenic activation in germanium crystals on the ground during fabrication and transportation generates long half-life radionuclides and contributes a considerable background. We simulated the production rates of cosmogenic radionuclides in germanium and calculated the specifi c activities of cosmogenic radionuclides according to the scheduled fabrication and transportation processes of $^{76}$Ge enriched germanium detectors. The impact of cosmogenic background in germanium crystals for the next generation CDEX experiment was assessed with the scheduled exposure history above ground.

physics.ins-det

TPMIL: Trainable Prototype Enhanced Multiple Instance Learning for Whole Slide Image Classification

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually formulated as a weakly supervised problem, which relies on multiple instance learning (MIL) based on patches of a WSI. In this paper, we aim to learn an optimal patch-level feature space by integrating prototype learning with MIL. To this end, we develop a Trainable Prototype enhanced deep MIL (TPMIL) framework for weakly supervised WSI classification. In contrast to the conventional methods which rely on a certain number of selected patches for feature space refinement, we softly cluster all the instances by allocating them to their corresponding prototypes. Additionally, our method is able to reveal the correlations between different tumor subtypes through distances between corresponding trained prototypes. More importantly, TPMIL also enables to provide a more accurate interpretability based on the distance of the instances from the trained prototypes which serves as an alternative to the conventional attention score-based interpretability. We test our method on two WSI datasets and it achieves a new SOTA. GitHub repository: https://github.com/LitaoYang-Jet/TPMIL

cs.CV

Identification of the anomalous fast bulk events in a p-type point contact germanium detector

The ultralow detection threshold, ultralow intrinsic background, and excellent energy resolution of p-type point-contact germanium detector are important for rare-event searches, in particular for the detection of direct dark matter interactions, coherent elastic neutrino-nucleus scattering, and neutrinoless double beta decay. Anomalous bulk events with an extremely fast rise time are observed in the CDEX-1B detector. We report a method of extracting fast bulk events from bulk events using a pulse shape simulation and reconstructed source experiment signature. Calibration data and the distribution of X-rays generated by intrinsic radioactivity verified that the fast bulk experienced a single hit near the passivation layer. The performance of this germanium detector indicates that it is capable of single-hit bulk spatial resolution and thus provides a background removal technique.

physics.ins-det

Leukocyte Classification using Multimodal Architecture Enhanced by Knowledge Distillation

Recently, a lot of automated white blood cells (WBC) or leukocyte classification techniques have been developed. However, all of these methods only utilize a single modality microscopic image i.e. either blood smear or fluorescence based, thus missing the potential of a better learning from multimodal images. In this work, we develop an efficient multimodal architecture based on a first of its kind multimodal WBC dataset for the task of WBC classification. Specifically, our proposed idea is developed in two steps - 1) First, we learn modality specific independent subnetworks inside a single network only; 2) We further enhance the learning capability of the independent subnetworks by distilling knowledge from high complexity independent teacher networks. With this, our proposed framework can achieve a high performance while maintaining low complexity for a multimodal dataset. Our unique contribution is two-fold - 1) We present a first of its kind multimodal WBC dataset for WBC classification; 2) We develop a high performing multimodal architecture which is also efficient and low in complexity at the same time.

eess.IV

Search for boosted dark matter with high-Z material in underground experiments

We propose to search for a boosted dark matter (DM) particle from astrophysical sources using an emulsion detector in deep underground facilities. We further propose using high-$Z$ material such as the lead for a larger DM-nucleus coherent scattering cross section above a threshold. The boosted DM will scatter into an excited DM. While the nuclear recoil energy is not detected, the decay products from the excited DM can be recorded by the proposed detector. Backgrounds such as the high energy solar neutrinos can be controlled by the reconstructed track topology. The proposed detector has the potential to find a boosted DM in the sub-GeV mass region, and in certain parameter space, an observation can be made while there is no sensitivity in other large-volume detectors such as Super-K.

hep-ph

Neutrino Portal to FIMP Dark Matter with an Early Matter Era

We study the freeze-in production of Feebly Interacting Massive Particle (FIMP) dark matter candidates through a neutrino portal. We consider a hidden sector comprised of a fermion and a complex scalar, with the lightest one regarded as a FIMP candidate. We implement the Type-I Seesaw mechanism for generating the masses of the Standard Model (SM) neutrinos and consider three heavy neutrinos, responsible for mediating the interactions between the hidden and the SM sectors. We assume that an early matter-dominated era (EMDE) took place for some period between inflation and Big Bang Nucleosynthesis, making the Universe to expand faster than in the standard radiation-dominated era. In this case, the hidden and SM sectors are easily decoupled and larger couplings between FIMPs and SM particles are needed from the relic density constraints. In this context, we discuss the dynamics of dark matter throughout the modified cosmic history, evaluate the relevant constraints of the model and discuss the consequences of the duration of the EMDE for the dark matter production. Finally, we show that if the heavy neutrinos are not part of the thermal bath, this scenario becomes testable through indirect detection searches.

hep-ph

Results of direct dark matter detection with CDEX experiment at CJPL

The China Dark Matter Experiment (CDEX), located at the China Jinping Underground Laboratory (CJPL) whose overburden is about 2400m rock, aims at direct searches of light Weakly Interacting Massive Particles (WIMPs). A single-element 994-gram p-type point contact (PPC) germanium detector (CDEX-1B) runs inside a solid passive shielding system. To achieve lower background, a prototype 10kg PPC germanium detector array (CDEX-10), consisting of three detector strings with three germanium crystals each, is directly immersed in the liquid nitrogen. With the energy threshold of 160eV, the limits on WIMP-nucleus scattering are set by energy spectra and annual modulation analysis, respectively. Incorporating Migdal effect, the data of CDEX-1B are re-analyzed to search sub-GeV WIMPs. Finally, the future plan of CDEX experiment in CJPL-II is introduced.

hep-ex