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arXiv · 1510.04818

Ultra-thin rigid endoscope: Two-photon imaging through a graded-index multi-mode fiber

Siddharth Sivankutty·Esben Ravn Andresen·Rosa Cossart·Géraud Bouwmans·Serge Monneret·Hervé Rigneault
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Abstract

Rigid endoscopes like graded-index (GRIN) lenses are known tools in biological imaging, but it is conceptually difficult to miniaturize them. In this letter, we demonstrate an ultra-thin rigid endoscope with a diameter of only 125 microns. In addition, we identify a domain where two-photon endoscopic imaging with fs-pulse excitation is possible. We validate the ultra-thin rigid endoscope consisting of a few cm of graded-index multi-mode fiber by using it to acquire optically sectioned two-photon fluorescence endoscopic images of three-dimensional samples.

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Siddharth Sivankutty, Esben Ravn Andresen, Rosa Cossart, Géraud Bouwmans, Serge Monneret, Hervé Rigneault. 2015-10-16. Ultra-thin rigid endoscope: Two-photon imaging through a graded-index multi-mode fiber. https://doi.org/10.1364/oe.24.000825

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